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Use¹

• SIMCOR is the combination of two cholesterol-lowering medications: niacin extended-release (NIASPAN®) and simvastatin. SIMCOR is used along with diet to lower levels of total cholesterol, LDL "bad" cholesterol, and triglycerides and to increase HDL "good" cholesterol.
  
  
• SIMCOR is used when treatment with both simvastatin and niacin extended-release is appropriate, and when diet and other non-drug measures alone have not been successful. Patients should stay on a diet low in saturated fat and cholesterol while taking this medicine.
  
  
• No additional benefit of SIMCOR on heart disease over and above that shown for niacin alone and simvastatin alone has been demonstrated.
  
  

Important Safety Information

• SIMCOR should not be used if you have liver problems, stomach ulcers, or serious bleeding problems; in women who are pregnant, may become pregnant, or nursing; and if you are allergic to any product ingredient.
  
  
• Contact your health care provider if symptoms of unexplained muscle pain, tenderness, or weakness occur, as this may be a sign of a serious but rare muscle disorder, from which rare cases of death have occurred. Also tell your health care provider about any other medications, vitamins, or nutritional supplements you are taking to avoid possible serious drug interactions.
  
  
• SIMCOR should not be substituted for equivalent doses of immediate-release niacin. Liver damage has been reported when substituting sustained-release niacin products with immediate-release niacin at equivalent doses. Always check with your health care provider before changing medication.
  
  
• SIMCOR should be used with caution if you consume large amounts of alcohol. Your health care provider may do simple blood tests before and during treatment with SIMCOR to check for liver problems.
  
  
• SIMCOR may cause an increase in blood sugar levels. If you have diabetes, you should report any changes in blood sugar levels to your health care provider.
  
  
• Women of childbearing age should use an effective method of birth control to prevent pregnancy while using SIMCOR. If you are pregnant, stop SIMCOR and contact your health care provider.
  
  
• Flushing (warmth, redness, itching, and/or tingling of the skin) is the most common side effect and may become less frequent over time. Additional symptoms may include rapid or pronounced heartbeat, shortness of breath, sweating, chills, dizziness, fainting, and/or swelling. Flushing may vary in severity and is more likely to occur when starting therapy or during dose increases. By taking SIMCOR at bedtime, flushing will most likely occur during sleep. If flushing wakes you up, take your time getting up, especially if feeling dizzy, faint, or taking blood pressure medications.
  
  
• Other common side effects may include headache, itching, nausea, back pain, and diarrhea.